This medication mimics the incretin hormone produced by the intestines, encouraging insulin secretion in response to meals while also inhibiting glucagon release
In a 68-week medical study of 1,961 adults living with obesity or excess weight, and who also had a related medical problem, lost an average of 15% of their body weight while taking semaglutide
In this large, propensity-matched, cohort study, individuals with obesity treated with tirzepatide were significantly more likely to achieve clinically meaningful weight loss and larger reductions in body weight compared with those treated with semaglutide, wrote first author Patricia J
Others never escalate further and transition directly into a maintenance phase
We are just beginning to understand the benefits of these drugs beyond weight loss alone, said Aronne
It causes a variety of uncomfortable or painful symptoms, and can be dangerous in severe cases